human fibroblasts — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1684	Nitisinone	NTBC,SC0735,Nitisone	Others , Reactive Oxygen Species
	Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.		Others , Reactive Oxygen Species
T1889	CP-640186	CP 640186	Acetyl-CoA Carboxylase
	CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.		Acetyl-CoA Carboxylase
T3622	CP-640186 hydrochloride	CP 640186 HCl	Acetyl-CoA Carboxylase
	CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit...		Acetyl-CoA Carboxylase
T2437	O4I2	O-4I2,O4I2	OCT
	O4I2 is an effective Oct3/4 inducer in various human cell lines including human fibroblasts.		OCT
T21653	1,4-DPCA		HIF/HIF Prolyl-Hydroxylase
	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).		HIF/HIF Prolyl-Hydroxylase
T36442L	(Hyp³)-Bradykinin acetate	(Hyp³)-Bradykinin acetate (37642-65-2 Free base)	Bradykinin Receptor
	(Hyp³)-Bradykinin acetate is an agonist of bradykinin B2 receptor and stimulates inositol phosphate production in cultured human fibroblasts.		Bradykinin Receptor
T24706	RBC10	RBC 10,RBC-10	GTPase
	RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.		GTPase
T4004	Concanavalin A		Apoptosis
	Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.		Apoptosis
TN7117	Regaloside I		Others
	Regaloside I is the monomeric component in lily. Regaloside I could be the main constituent in protecting human dermal fibroblasts from UVA-induced morphological changes [1].		Others
T5295	1-Hydroxyoctadecane	1-Octadecanol,Stearyl alcohol,Octadecanol	Others , Endogenous Metabolite
	1-Hydroxyoctadecane (OctadecanolOctadecanol) is a fatty alcohol present in human and is normally incorporated into plasmalogen lipids. Sjogren-Larsson syndrome is defined by the triad of ichthyosis, mental retardation, a...		Others , Endogenous Metabolite
T3768	Epifriedelanol	Epifriedelinol	Others
	Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary ...		Others
T4100	AS8351	NSC51355,AS-8351,AS 8351	Histone Demethylase
	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas...		Histone Demethylase
T5120	Rhamnose	6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel , Endogenous Metabolite
	Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind...		Calcium Channel , Endogenous Metabolite
T5279	Ethylmalonic acid	alpha-Carboxybutyrate,2-Ethylmalonic acid	Others , Endogenous Metabolite
	Ethylmalonic acid (alpha-Carboxybutyrate) can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be as...		Others , Endogenous Metabolite
T2S2043	Dracorhodin perchlorate	Dracorhodin perochlorate,Dracohodin perochlorate	Apoptosis , Others
	Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate...		Apoptosis , Others
T38293	4-CPPC		Others
	4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concen...		Others
TP2341	Hexapeptide-11	Peptamide 6,Fvapfp,Phe-val-ala-pro-phe-pro
	Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.
T4430	Isosaponarin		Others
	Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.		Others
T69502	HSP47 inhibitor III
	HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts.
T22490	2,3-DCPE hydrochloride		Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.		Others